All Phenotypes Iqcf1<em1Zdq> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Iqcf1^em1Zdq
endonuclease-mediated mutation 1, Zhongdong Qiao
MGI:5751515

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Iqcf1^em1Zdq/Iqcf1^em1Zdq	Not Specified	MGI:5751516

Allelic Composition	Iqcf1^em1Zdq/Iqcf1^em1Zdq
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqcf1^em1Zdq mutation (0 available); any Iqcf1 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:228595 )

N	• total spermatozoa number is normal

asthenozoospermia ( J:228595 )

• reduced total sperm motility and progressive sperm motility before and after capacitation

• reduced average path, straight-line and curvilinear velocities

• however, sperm exhibit normal amplitude of the lateral head displacement, beat/cross frequency, straightness and linearity

reduced male fertility ( J:228595 )

impaired acrosome reaction ( J:228595 )

• reduced in vitro A23187-induced acrosome reaction of the capacitated spermatozoa

• however, spontaneous acrosome reaction is normal

cellular

asthenozoospermia ( J:228595 )

• reduced total sperm motility and progressive sperm motility before and after capacitation

• reduced average path, straight-line and curvilinear velocities

• however, sperm exhibit normal amplitude of the lateral head displacement, beat/cross frequency, straightness and linearity

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