Phenotypes associated with this allele

• Allele Symbol: Sox17^SHIVA
• Allele Name: Seric and Hepatic Impaired VAnin
• Allele ID: MGI:5751535
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sox17^SHIVA/Sox17^+	either: C57BL/6-Sox17^SHIVA or (involves: C57BL/6 * C3H/HeN)	MGI:5751539

Genotype
MGI:5751539

ht1

• Allelic Composition: Sox17^SHIVA/Sox17⁺
• Genetic Background: either: C57BL/6-Sox17^SHIVA or (involves: C57BL/6 * C3H/HeN)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal peroxisome morphology ( J:219119 )

♀ • 2-fold reduction in liver peroxisomes

endocrine/exocrine glands

ovary atrophy ( J:219119 )

♀ • partial atrophy of ovaries

growth/size/body

decreased birth body size ( J:219119 )

♀

homeostasis/metabolism

decreased fasting circulating glucose level ( J:219119 )

♀ • 14 hours, but not 48 hours, after fasting, mutants are more hypoglycemic than controls

decreased circulating ketone body level ( J:219119 )

♀ • 48 hours after fasting, mutants show impaired production of ketone bodies, producing reduced beta-hydroxybutyrate levels

decreased circulating HDL cholesterol level ( J:219119 )

♀ • mice exhibit lower HDL cholesterol levels

abnormal enzyme/coenzyme level ( J:219119 )

♀ • reduction in serum pantetheinase levels

decreased liver triglyceride level ( J:219119 )

♀ • in the fed condition, mice exhibit lower levels of triglycerides in the liver-derived VLDL fraction

♀ • however, after fasting, triglyceride levels are similar to wild-type levels

abnormal metabolism ( J:219119 )

♀ • mice show impaired metabolic adaptation to fasting

abnormal lipid metabolism ( J:219119 )

♀ • impaired lipid metabolism under fed conditions and reduced adaptation to fasting

♀ • fenofibrate treatment of fasted mice does not lower liver steatosis as it does in wild-type mice

liver/biliary system

decreased liver triglyceride level ( J:219119 )

♀ • in the fed condition, mice exhibit lower levels of triglycerides in the liver-derived VLDL fraction

♀ • however, after fasting, triglyceride levels are similar to wild-type levels

reproductive system

ovary atrophy ( J:219119 )

♀ • partial atrophy of ovaries

reduced female fertility ( J:219119 )

♀