Analysis Tools
mortality/aging
|
• mice die between E10.5 and E11.5
|
cardiovascular system
|
• disorganized and thin arterial branches
|
|
• disorganized and thin
|
|
• disorganized and thin
• absent in some severely affected mice
|
|
• in most mice the umbilical artery becomes a big ball
|
|
• disorganized and thin
|
|
• lack of vitelline circulation, reduced major vitelline artery caliber and branching, reduced tip cell formation, and poorly organized endothelial cells with enlarged endothelial-lined lacunae between the endoderm and mesoderm layers
|
|
• defective cardiac valve formation
|
embryo
|
• in most mice the umbilical artery becomes a big ball
|
|
• lack of vitelline circulation, reduced major vitelline artery caliber and branching, reduced tip cell formation, and poorly organized endothelial cells with enlarged endothelial-lined lacunae between the endoderm and mesoderm layers
|
|
• at E9.5
• severe at E10.5
|
|
• failure of primary vascular plexus remodeling
|
growth/size/body
|
• at E9.5
• severe at E10.5
|
muscle
