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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clk2tm1.1Ppgr
targeted mutation 1.1, Pere Puigserver
MGI:5751695
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Clk2tm1.1Ppgr/Clk2tm1.1Ppgr
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6NTac * FVB/N MGI:5751747


Genotype
MGI:5751747
cn1
Allelic
Composition		 Clk2tm1.1Ppgr/Clk2tm1.1Ppgr
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clk2tm1.1Ppgr mutation (0 available); any Clk2 mutation (38 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal fatty acid oxidation ( J:229283 )
• mice fed a high fat diet exhibit increased fatty acid and ketogenesis with increased beta-hydroxybutyrate serum levels in fasted mice
decreased respiratory quotient ( J:229283 )
• in fasted high-fat diet fed mice
decreased liver triglyceride level ( J:229283 )
• in fasted high-fat diet fed mice, but not refed mice

liver/biliary system
decreased liver triglyceride level ( J:229283 )
• in fasted high-fat diet fed mice, but not refed mice

cellular
abnormal fatty acid oxidation ( J:229283 )
• mice fed a high fat diet exhibit increased fatty acid and ketogenesis with increased beta-hydroxybutyrate serum levels in fasted mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory