Phenotypes associated with this allele

• Allele Symbol: Psen1^tm5.1Shn
• Allele Name: targeted mutation 5.1, Jie Shen
• Allele ID: MGI:5751734
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psen1^tm5.1Shn/Psen1^tm5.1Shn	involves: 129 * C57BL/6 * C57BL/6J	MGI:5754379

Genotype
MGI:5754379

hm1

• Allelic Composition: Psen1^tm5.1Shn/Psen1^tm5.1Shn
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:219929 )

embryo

short rostral-caudal axis ( J:219929 )

limbs/digits/tail

short tail ( J:219929 )

kinked tail ( J:219929 )

nervous system

decreased cortical ventricular zone thickness ( J:219929 )

• thinning of the ventricular zone within the developing telencephalon at E16.5

• number of proliferating cells is reduced in the ventricular zone

abnormal lateral ganglionic eminence morphology ( J:219929 )

• thinning of the ventricular zone within the lateral ganglionic eminence at E16.5