Phenotypes associated with this allele

• Allele Symbol: Setdb2^tm1Desr
• Allele Name: targeted mutation 1, David E Symer
• Allele ID: MGI:5751798
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Setdb2^tm1Desr/Setdb2^tm1Desr	B6.Cg-Setdb2^tm1Desr	MGI:5751805

Genotype
MGI:5751805

hm1

• Allelic Composition: Setdb2^tm1Desr/Setdb2^tm1Desr
• Genetic Background: B6.Cg-Setdb2^tm1Desr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased neutrophil cell number ( J:222611 )

• in a model of LPS-induced pulmonary neutrophilia

abnormal response to infection ( J:222611 )

• in a model of LPS-induced pulmonary neutrophilia, mice exhibit increased CXCL1 secretion, elevated total cell infiltrate in bronchoalveolar lavage fluid and neutrophilia compared with wild-type mice

• mice infected with S. pneumonia exhibit increased CXCL1, CXCL2, IL6 and IL10 secretion compared with wild-type cells

• however, the number of macrophages is normal in a model of LPS-induced pulmonary neutrophilia

increased susceptibility to bacterial infection ( J:222611 )

• mice superinfection of influenza virus-infected mice with S. pneumonia exhibit increased CXCL1 secretion, lower bacterial burden, and ameliorated pathological findings with diminished signs of pneumonia, including bronchitis, endothelialitis and inflammatory infiltrates compared with wild-type mice

hematopoietic system

increased neutrophil cell number ( J:222611 )

• in a model of LPS-induced pulmonary neutrophilia