Phenotypes associated with this allele

• Allele Symbol: Sars1^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5751876
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sars1^tm1.1(KOMP)Vlcg/Sars1^tm1.1(KOMP)Vlcg	B6N(Cg)-Sars1^tm1.1(KOMP)Vlcg/2J	MGI:6263420
hm2	Sars1^tm1.1(KOMP)Vlcg/Sars1^tm1.1(KOMP)Vlcg	C57BL/6N-Sars1^tm1.1(KOMP)Vlcg/JMmucd	MGI:6376229
ht3	Sars1^tm1.1(KOMP)Vlcg/Sars1^+	B6N(Cg)-Sars1^tm1.1(KOMP)Vlcg/2J	MGI:6263419

Genotype
MGI:6263420

hm1

• Allelic Composition: Sars1^{tm1.1(KOMP)Vlcg}/Sars1^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Sars1^{tm1.1(KOMP)Vlcg}/2J
• Cell Lines: 18995A-G10

Data Sources

IMPC Data for Sars1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6376229

hm2

• Allelic Composition: Sars1^{tm1.1(KOMP)Vlcg}/Sars1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Sars1^{tm1.1(KOMP)Vlcg}/JMmucd
• Cell Lines: 18995A-G10

Sars1^{tm1.1(KOMP)Vlcg}/Sars1^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulas. Morulas in vitro fail to hatch from the zona pellucida with apparent cell death, never reaching a morphological blastocyst stage.

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at lower Mendelian ratios at E3.5 (11% versus expected 25%, n=45) and appear to arrest/die prior to blastocyst formation; no embryos or excess resorption sites are observed at E7.5

embryo

failure of blastocyst formation ( J:279207 )

• in vitro, embryos fail to hatch and never reach a morphological blastocyst stage after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, embryos fail to hatch from the zona pellucida with apparent cell death after 3 days in culture

abnormal morula morphology ( J:279207 )

• embryos recovered at E3.5 appear as dying morulae

Genotype
MGI:6263419

ht3

• Allelic Composition: Sars1^{tm1.1(KOMP)Vlcg}/Sars1⁺
• Genetic Background: B6N(Cg)-Sars1^{tm1.1(KOMP)Vlcg}/2J
• Cell Lines: 18995A-G10

Data Sources

IMPC Data for Sars1

behavior/neurological

decreased grip strength ( J:211773 )

♀

IMPC - JAX

homeostasis/metabolism

improved glucose tolerance ( J:211773 )

IMPC - JAX

pigmentation

abnormal iris pigmentation ( J:211773 )

IMPC - JAX

vision/eye

abnormal iris pigmentation ( J:211773 )

IMPC - JAX