Phenotypes associated with this allele

• Allele Symbol: Tg(IgkH280)934Dvs
• Allele Name: transgene insertion 934, David V Serreze
• Allele ID: MGI:5752042
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Emv30^b/Emv30^b Prkdc^scid/Prkdc^scid Tg(IghH280)48Dvs/? Tg(IgkH280)934Dvs/?	NOD.Cg-Emv30^b Prkdc^scid Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs	MGI:6303746
cx2	Tg(IghH280)48Dvs/? Tg(IgkH280)934Dvs/?	NOD/ShiLtDvs-Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs	MGI:6303754
tg3	Tg(IgkH280)934Dvs/?	NOD/ShiLtDvs-Tg(IgkH280)934Dvs/J	MGI:5752048

Genotype
MGI:6303746

cx1

• Allelic Composition: Emv30^b/Emv30^b; Prkdc^scid/Prkdc^scid; Tg(IghH280)48Dvs/?; Tg(IgkH280)934Dvs/?
• Genetic Background: NOD.Cg-Emv30^b Prkdc^scid Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:274578 )

N • mice homozygous for the scid mutation do not develop insulitis despite the NOD background and pro-diabetic transgenes

Genotype
MGI:6303754

cx2

• Allelic Composition: Tg(IghH280)48Dvs/?; Tg(IgkH280)934Dvs/?
• Genetic Background: NOD/ShiLtDvs-Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs

immune system

increased susceptibility to autoimmune diabetes ( J:274578 )

Genotype
MGI:5752048

tg3

• Allelic Composition: Tg(IgkH280)934Dvs/?
• Genetic Background: NOD/ShiLtDvs-Tg(IgkH280)934Dvs/J

endocrine/exocrine glands

insulitis ( J:274578 )

• mice develop insulitis earlier than NOD/ShiLtDvs controls

immune system

insulitis ( J:274578 )

• mice develop insulitis earlier than NOD/ShiLtDvs controls

increased susceptibility to autoimmune diabetes ( J:274578 )

• 90-95% of mice develop type 1 diabetes by 20 weeks of age

• onset is accelerated as compared to NOD/ShiLtDvs controls (80-90% by 30-40 weeks of age)