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Allele Symbol Allele Name Allele ID |
Otud5tm1Vmd targeted mutation 1, Vishva M Dixit MGI:5752247 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased IL17+ type 3 innate lymphoid cells
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• increased IL17+ type 3 innate lymphoid cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in anti-CD3 antibody-injected mice
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| N |
• regulatory T cells exhibit normal suppressive function and function in a T cell transfer model of colitis
• mice do not exhibit any signs of autoimmunity
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• anti-CD3 antibody-injected mice exhibit more severe inflammation in the lamina propria of the small intestine and with increased epithelial cell proliferation and death compared with control mice
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• 2- to 3-fold reduction in single positive thymocytes
• however, the number of naive and memory CD4+ T cells are normal
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• CD4+ T cells stimulated with PMA and ionomycin exhibit more Th17 cell differentiation compared with control cells
• increased IL17+ CD4+ T cells among intraepithelial lymphocytes
• increased Th17 cells in the small intestine, spleen and lymph node following injection of anti-CD3 antibodies
• however, Th2 cell differentiation is normal
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• in the periphery but not the thymus
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• following injection of anti-CD3 antibodies
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• increased IL17A in CD8+ T cell from naive mice and regulatory T cells after TCR stimulation
• increased IL17F in Th17 cells derived with TGFbeta and IL6 that persists after secondary and tertiary TCR stimulation
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• in Th17 cells derived with TGFbeta and IL6
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• in Th17 cells derived with TGFbeta and IL6
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• following injection of anti-CD3 antibodies
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• in anti-CD3 antibody-injected mice
|
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• anti-CD3 antibody-injected mice exhibit more severe inflammation in the lamina propria of the small intestine and with increased epithelial cell proliferation and death compared with control mice
|
|
• 2- to 3-fold reduction in single positive thymocytes
• however, the number of naive and memory CD4+ T cells are normal
|
|
• 2- to 3-fold reduction in single positive thymocytes
• however, the number of naive and memory CD4+ T cells are normal
|
|
• CD4+ T cells stimulated with PMA and ionomycin exhibit more Th17 cell differentiation compared with control cells
• increased IL17+ CD4+ T cells among intraepithelial lymphocytes
• increased Th17 cells in the small intestine, spleen and lymph node following injection of anti-CD3 antibodies
• however, Th2 cell differentiation is normal
|
|
• in the periphery but not the thymus
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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