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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Otud5tm1Vmd
targeted mutation 1, Vishva M Dixit
MGI:5752247
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Otud5tm1Vmd/Otud5tm1Vmd
Tg(Vav1-cre)#Cgp/0
involves: C57BL/6 MGI:5896451
cn2
Otud5tm1Vmd/Otud5tm1Vmd
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 MGI:5896450


Genotype
MGI:5896451
cn1
Allelic
Composition
Otud5tm1Vmd/Otud5tm1Vmd
Tg(Vav1-cre)#Cgp/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otud5tm1Vmd mutation (0 available); any Otud5 mutation (9 available)
Tg(Vav1-cre)#Cgp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased IL17+ type 3 innate lymphoid cells

hematopoietic system
• increased IL17+ type 3 innate lymphoid cells




Genotype
MGI:5896450
cn2
Allelic
Composition
Otud5tm1Vmd/Otud5tm1Vmd
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otud5tm1Vmd mutation (0 available); any Otud5 mutation (9 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

immune system
N
• regulatory T cells exhibit normal suppressive function and function in a T cell transfer model of colitis
• mice do not exhibit any signs of autoimmunity
• anti-CD3 antibody-injected mice exhibit more severe inflammation in the lamina propria of the small intestine and with increased epithelial cell proliferation and death compared with control mice
• 2- to 3-fold reduction in single positive thymocytes
• however, the number of naive and memory CD4+ T cells are normal
• CD4+ T cells stimulated with PMA and ionomycin exhibit more Th17 cell differentiation compared with control cells
• increased IL17+ CD4+ T cells among intraepithelial lymphocytes
• increased Th17 cells in the small intestine, spleen and lymph node following injection of anti-CD3 antibodies
• however, Th2 cell differentiation is normal
• in the periphery but not the thymus
• following injection of anti-CD3 antibodies
• increased IL17A in CD8+ T cell from naive mice and regulatory T cells after TCR stimulation
• increased IL17F in Th17 cells derived with TGFbeta and IL6 that persists after secondary and tertiary TCR stimulation
• in Th17 cells derived with TGFbeta and IL6
• in Th17 cells derived with TGFbeta and IL6

homeostasis/metabolism
• following injection of anti-CD3 antibodies

digestive/alimentary system
• anti-CD3 antibody-injected mice exhibit more severe inflammation in the lamina propria of the small intestine and with increased epithelial cell proliferation and death compared with control mice

endocrine/exocrine glands
• 2- to 3-fold reduction in single positive thymocytes
• however, the number of naive and memory CD4+ T cells are normal

hematopoietic system
• 2- to 3-fold reduction in single positive thymocytes
• however, the number of naive and memory CD4+ T cells are normal
• CD4+ T cells stimulated with PMA and ionomycin exhibit more Th17 cell differentiation compared with control cells
• increased IL17+ CD4+ T cells among intraepithelial lymphocytes
• increased Th17 cells in the small intestine, spleen and lymph node following injection of anti-CD3 antibodies
• however, Th2 cell differentiation is normal
• in the periphery but not the thymus





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory