Phenotypes associated with this allele

• Allele Symbol: Col1a1^{tm1(tetO-U2AF1*S34F)Mjwa}
• Allele Name: targeted mutation 1, Matthew J Walter
• Allele ID: MGI:5752388
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Col1a1^tm1(tetO-U2AF1*S34F)Mjwa/Col1a1^+ Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/?	involves: 129S4/SvJae * C57BL/6	MGI:5754807

Genotype
MGI:5754807

cx1

• Allelic Composition: Col1a1^{tm1(tetO-U2AF1*S34F)Mjwa}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:221403 )

• lethally-irradiated mice transplanted with mutant bone marrow and treated with doxycycline exhibit altered hematopoiesis, showing peripheral blood leukopenia, and changes in the distribution of mature hematopoietic lineages in the peripheral blood and spleen (reduction in B cells and monocytes, increase in neutrophils) and an increase in the frequency of progenitor cells in the bone marrow and spleen as well as the frequency of progenitor cells that are cycling in the bone marrow

• however, lethally-irradiated mice transplanted with mutant bone marrow and treated with doxycycline do not develop myelodysplastic syndrome or acute myeloid leukemia after at least 1 year of continuous doxycycline