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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tulp3tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:5752546
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tulp3tm1c(EUCOMM)Hmgu/Tulp3tm1c(EUCOMM)Hmgu
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 * C57BL/6N * DBA * SJL MGI:6392317
cn2
Tulp3tm1c(EUCOMM)Hmgu/Tulp3tm1c(EUCOMM)Hmgu
Pkd1tm2Ggg/Pkd1+
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL MGI:6392322
cn3
Tulp3tm1c(EUCOMM)Hmgu/Tulp3+
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL MGI:6392330
cn4
Tulp3tm1c(EUCOMM)Hmgu/Tulp3tm1c(EUCOMM)Hmgu
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL MGI:6392333


Genotype
MGI:6392317
cn1
Allelic
Composition
Tulp3tm1c(EUCOMM)Hmgu/Tulp3tm1c(EUCOMM)Hmgu
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6N * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax8-rtTA2S*M2)1Koes mutation (3 available)
Tg(tetO-cre)1Jaw mutation (6 available)
Tulp3tm1c(EUCOMM)Hmgu mutation (2 available); any Tulp3 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice treated with Dox at P28 for 2 weeks and analyzed at 41-42 weeks of age show slow development of kidney cysts
• mice treated with Dox at P0 and analyzed at P14 show a modest kidney phenotype, with a few cysts
• however, blood urea nitrogen levels are normal in Dox treated mice
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show a modest kidney phenotype, with mild tubule dilatations

growth/size/body
• mice treated with Dox at P28 for 2 weeks and analyzed at 41-42 weeks of age show slow development of kidney cysts
• mice treated with Dox at P0 and analyzed at P14 show a modest kidney phenotype, with a few cysts
• however, blood urea nitrogen levels are normal in Dox treated mice




Genotype
MGI:6392322
cn2
Allelic
Composition
Tulp3tm1c(EUCOMM)Hmgu/Tulp3tm1c(EUCOMM)Hmgu
Pkd1tm2Ggg/Pkd1+
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm2Ggg mutation (1 available); any Pkd1 mutation (154 available)
Tg(Pax8-rtTA2S*M2)1Koes mutation (3 available)
Tg(tetO-cre)1Jaw mutation (6 available)
Tulp3tm1c(EUCOMM)Hmgu mutation (2 available); any Tulp3 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show development of kidney cysts, with increased kidney weight/body weight ratio and more numerous and larger cysts than single conditional Tulp3 homozygotes
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show a modest elevation of kidney weight/body weight ratio
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show larger tubule dilations

homeostasis/metabolism
• mice treated with Dox at P0 show elevated blood urea nitrogen levels
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show no differences in blood urea nitrogen levels

growth/size/body
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show development of kidney cysts, with increased kidney weight/body weight ratio and more numerous and larger cysts than single conditional Tulp3 homozygotes
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show a modest elevation of kidney weight/body weight ratio




Genotype
MGI:6392330
cn3
Allelic
Composition
Tulp3tm1c(EUCOMM)Hmgu/Tulp3+
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm2Ggg mutation (1 available); any Pkd1 mutation (154 available)
Tg(Pax8-rtTA2S*M2)1Koes mutation (3 available)
Tg(tetO-cre)1Jaw mutation (6 available)
Tulp3tm1c(EUCOMM)Hmgu mutation (2 available); any Tulp3 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate cystic phenotype, with cystic index lower than conditional Pkd1 homozygotes but higher than in double Tulp3 and Pkd1 homozygotes
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate kidney weight/body weight ratio, with lower ratio than conditional Pkd1 homozygotes but higher ratio than in double Tulp3 and Pkd1 homozygotes

homeostasis/metabolism
• mice treated with Dox at P0 show increased blood urea nitrogen levels at P14
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate level of blood urea nitrogen, with lower level than conditional Pkd1 homozygotes but higher level than in double Tulp3 and Pkd1 homozygotes

growth/size/body
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate cystic phenotype, with cystic index lower than conditional Pkd1 homozygotes but higher than in double Tulp3 and Pkd1 homozygotes
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate kidney weight/body weight ratio, with lower ratio than conditional Pkd1 homozygotes but higher ratio than in double Tulp3 and Pkd1 homozygotes




Genotype
MGI:6392333
cn4
Allelic
Composition
Tulp3tm1c(EUCOMM)Hmgu/Tulp3tm1c(EUCOMM)Hmgu
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm2Ggg mutation (1 available); any Pkd1 mutation (154 available)
Tg(Pax8-rtTA2S*M2)1Koes mutation (3 available)
Tg(tetO-cre)1Jaw mutation (6 available)
Tulp3tm1c(EUCOMM)Hmgu mutation (2 available); any Tulp3 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• however, mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show no differences in kidney weight/body weight ratio

homeostasis/metabolism
• mice treated with Dox at P0 show increased blood urea nitrogen levels at P14
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show no differences in blood urea nitrogen levels

growth/size/body
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• however, mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show no differences in kidney weight/body weight ratio





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory