Analysis Tools
mortality/aging
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• following PTZ-induced seizures
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• median survival is 115 days with no mice surviving past 175 days with no wounds or major pathology to explain sudden death
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nervous system
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• shorter latency to seizures induced by PTZ and increased death
• however, duration of seizures is normal
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• in two mice
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• in one mouse
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• median survival is 115 days with no mice surviving past 175 days with no wounds or major pathology to explain sudden death
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astrocytosis
(
J:260943
)
|
• thicker and disorganized in layer V cortical neurons
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• enlarged and dysplastic neurons with abnormal cytoplasmic accumulation
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behavior/neurological
| N |
• unlike constitutive knock-out mice, conditional knock-out mice do not exhibit a hunchback phenotype
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• hindlimb clasping after 60 days of age
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• shorter latency to seizures induced by PTZ and increased death
• however, duration of seizures is normal
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• in two mice
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• in one mouse
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growth/size/body
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• in male, but not female, mice from the time of weaning and persisting through adulthood
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megacephaly
(
J:260943
)
homeostasis/metabolism
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• following PTZ-induced seizures
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skeleton
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• with decreased neuronal density in deep layers
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