All Phenotypes Ace2<em#Yngh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ace2^em#Yngh
endonuclease-mediated mutation, Huanming Yang
MGI:5752578

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Ace2^em#Yngh/Y	involves: Kunming	MGI:5752581

Allelic Composition	Ace2^em#Yngh/Y
Genetic Background	involves: Kunming

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2^em#Yngh mutation (0 available); any Ace2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

diarrhea ( J:221616 )

• in DSS-treated mice

decreased colon length ( J:221616 )

• in DSS-treated mice

increased susceptibility to induced colitis ( J:221616 )

• DSS-treated mice exhibit more severe diarrhea, increased weight loss, increased colon shortening with increased inflammatory cell infiltration compared with wild-type mice

growth/size/body

increased susceptibility to weight loss ( J:221616 )

• in DSS-treated mice

immune system

increased susceptibility to induced colitis ( J:221616 )

• DSS-treated mice exhibit more severe diarrhea, increased weight loss, increased colon shortening with increased inflammatory cell infiltration compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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