Phenotypes associated with this allele

• Allele Symbol: Sprtn^tm1.2Yjm
• Allele Name: targeted mutation 1.2, Yuichi J Machida
• Allele ID: MGI:5752656
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sprtn^tm1.2Yjm/Sprtn^tm1.2Yjm	involves: 129S/SvEv * C57BL/6	MGI:5752767
ht2	Sprtn^tm1Yjm/Sprtn^tm1.2Yjm	involves: 129S/SvEv * C57BL/6	MGI:5752766

Genotype
MGI:5752767

hm1

• Allelic Composition: Sprtn^tm1.2Yjm/Sprtn^tm1.2Yjm
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:225198 )

• however, embryos are present at E3.5

• no mice are found at E7.5 to E13.5 and likely die prior to implantation

embryo

decreased inner cell mass proliferation ( J:225198 )

• in culture

absent blastocoele ( J:225198 )

• in culture

cellular

decreased inner cell mass proliferation ( J:225198 )

• in culture

Genotype
MGI:5752766

ht2

• Allelic Composition: Sprtn^tm1Yjm/Sprtn^tm1.2Yjm
• Genetic Background: involves: 129S/SvEv * C57BL/6

mortality/aging

preweaning lethality, complete penetrance ( J:225198 )

• no mice are produced from crossing heterozygous mice

cellular

abnormal cell nucleus morphology ( J:225198 )

• increased numbers of micronuclei in mouse embryonic fibroblasts indicating genomic instability

decreased fibroblast proliferation ( J:225198 )

• in mouse embryonic fibroblasts

chromosomal instability ( J:225198 )

• increased numbers of micronuclei in mouse embryonic fibroblasts indicating genomic instability