All Phenotypes Cul3<tm1.1Arte> MGI Mouse

increased aorta wall thickness ( J:229424 )

hypertension ( J:229424 )

• mice under general anesthesia exhibit higher blood pressure

abnormal blood vessel physiology ( J:229424 )

• the systolic aortic pressure wave is augmented while the diastolic relaxation is slowed, suggesting early wave reflection of the pressure wave and compliance changes indicating vascular stiffness

increased vasoconstriction ( J:229424 )

• maximal constrictor response to intravenous administration of phenylephrine and angiotensin II are higher than in wild-type mice

decreased body weight ( J:229424 )

decreased body length ( J:229424 )

increased circulating aldosterone level ( J:229424 )

increased circulating magnesium level ( J:229424 )

increased circulating phosphate level ( J:229424 )

hyperkalemia ( J:229424 )

increased circulating chloride level ( J:229424 )

• mice exhibit hyperchloremia

abnormal pH regulation ( J:229424 )

• pH is maintained by an increased respiratory drive to increase CO2 removal and hence reduced total CO2 and pCO2 levels

metabolic acidosis ( J:229424 )

• compensated metabolic acidosis

increased vasoconstriction ( J:229424 )

• maximal constrictor response to intravenous administration of phenylephrine and angiotensin II are higher than in wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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