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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cul3tm1.1Arte
targeted mutation 1.1, TaconicArtemis
MGI:5752857
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cul3tm1.1Arte/Cul3tm1.1Arte involves: C57BL/6J * C57BL/6N MGI:5752859
ht2
Cul3tm1.1Arte/Cul3+ involves: C57BL/6J * C57BL/6N MGI:5752860


Genotype
MGI:5752859
hm1
Allelic
Composition
Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul3tm1.1Arte mutation (0 available); any Cul3 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygotes are born




Genotype
MGI:5752860
ht2
Allelic
Composition
Cul3tm1.1Arte/Cul3+
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul3tm1.1Arte mutation (0 available); any Cul3 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice under general anesthesia exhibit higher blood pressure
• the systolic aortic pressure wave is augmented while the diastolic relaxation is slowed, suggesting early wave reflection of the pressure wave and compliance changes indicating vascular stiffness
• maximal constrictor response to intravenous administration of phenylephrine and angiotensin II are higher than in wild-type mice

growth/size/body

homeostasis/metabolism
• mice exhibit hyperchloremia
• pH is maintained by an increased respiratory drive to increase CO2 removal and hence reduced total CO2 and pCO2 levels
• compensated metabolic acidosis

muscle
• maximal constrictor response to intravenous administration of phenylephrine and angiotensin II are higher than in wild-type mice





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory