Phenotypes associated with this allele

• Allele Symbol: Col2a1^mc13
• Allele Name: mc13
• Allele ID: MGI:5752936
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Col2a1^mc13/Col2a1^mc13	involves: C57BL/6J * FVB/NJ	MGI:5774427

Genotype
MGI:5774427

hm1

• Allelic Composition: Col2a1^mc13/Col2a1^mc13
• Genetic Background: involves: C57BL/6J * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal head shape, shortened, thickened limbs and skeletal abnormalities in Col2a1^mc13/Col2a1^mc13 embryos

growth/size/body

abnormal head shape ( J:225386 )

• heads are abnormally shaped at E18.5

microcephaly ( J:225386 )

• mild microcephaly in some mutants at E18.5

• head length is decreased in affected mutants

• however, brain is normally patterned

craniofacial

short mandible ( J:225386 )

• at E18.5

abnormal head shape ( J:225386 )

• heads are abnormally shaped at E18.5

skeleton

short mandible ( J:225386 )

• at E18.5

abnormal limb long bone morphology ( J:225386 )

decreased length of long bones ( J:225386 )

• all long bones examined are significantly shorter than wild-type at E18.5

short humerus ( J:225386 )

• at E18.5

short radius ( J:225386 )

• at E18.5

short ulna ( J:225386 )

• at E18.5

short femur ( J:225386 )

• at E18.5

short fibula ( J:225386 )

• at E18.5

short tibia ( J:225386 )

• at E18.5

increased diameter of long bones ( J:225386 )

• all long bones examined are significantly wider than wild-type at E18.5

increased diameter of humerus ( J:225386 )

• at E18.5

increased diameter of radius ( J:225386 )

• at E18.5

increased diameter of ulna ( J:225386 )

• at E18.5

increased diameter of femur ( J:225386 )

• at E18.5

increased diameter of fibula ( J:225386 )

• at E18.5

increased diameter of tibia ( J:225386 )

• at E18.5

limbs/digits/tail

abnormal limb morphology ( J:225386 )

• limbs are abnormally shortened and thickened at E18.5

abnormal limb long bone morphology ( J:225386 )

increased diameter of humerus ( J:225386 )

• at E18.5

short humerus ( J:225386 )

• at E18.5

short radius ( J:225386 )

• at E18.5

increased diameter of radius ( J:225386 )

• at E18.5

short ulna ( J:225386 )

• at E18.5

increased diameter of ulna ( J:225386 )

• at E18.5

short femur ( J:225386 )

• at E18.5

increased diameter of femur ( J:225386 )

• at E18.5

increased diameter of fibula ( J:225386 )

• at E18.5

short fibula ( J:225386 )

• at E18.5

increased diameter of tibia ( J:225386 )

• at E18.5

short tibia ( J:225386 )

• at E18.5

short limbs ( J:225386 )

• at E18.5