Phenotypes associated with this allele

• Allele Symbol: Ntn1^tm1.2Tek
• Allele Name: targeted mutation 1.2, Timothy E Kennedy
• Allele ID: MGI:5752968
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntn1^tm1.2Tek/Ntn1^tm1.2Tek	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL	MGI:5755388

Genotype
MGI:5755388

hm1

• Allelic Composition: Ntn1^tm1.2Tek/Ntn1^tm1.2Tek
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:227232 )

• embryonic lethality by E14.5

nervous system

abnormal axon guidance ( J:227232 )

• few axons cross midline to form spinal commissure

• misguidance of sensory axons projecting from dorsal root ganglion into dorsal spinal cord results in a disrupted dorsal root entry zone

• TrkA- positive sensory axons are present in spinal cord

• mislocalized longitudinal axon bundles

abnormal spinal cord ependymal layer morphology ( J:227232 )

• thinning in ventricular zone in E14.5 embryos

abnormal spinal cord ventral commissure morphology ( J:227232 )

• absence of ventral spinal commissure observed at E10.5, E12.5 and E14.5

• dorsal-ventral height of the commissure at E14.5 is substantially less than wild-type

abnormal dorsal spinal root morphology ( J:227232 )

• disrupted dorsal root entry zone

abnormal spinal cord central canal morphology ( J:227232 )

• central canal is larger than wild-type

cellular

abnormal axon guidance ( J:227232 )

• few axons cross midline to form spinal commissure

• misguidance of sensory axons projecting from dorsal root ganglion into dorsal spinal cord results in a disrupted dorsal root entry zone

• TrkA- positive sensory axons are present in spinal cord

• mislocalized longitudinal axon bundles