Phenotypes associated with this allele

• Allele Symbol: Cd84^tm1Beni
• Allele Name: targeted mutation 1, Bernhard Nieswandt
• Allele ID: MGI:5753066
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd84^tm1Beni/Cd84^tm1Beni	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5774440

Genotype
MGI:5774440

hm1

• Allelic Composition: Cd84^tm1Beni/Cd84^tm1Beni
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:225659 )

• homozygotes are viable and grossly normal with no alterations in hematologic parameters, platelet count and lifespan, tail bleeding times (hemostasis), and arterial thrombus formation after mechanical or FeCl3-induced injury

• in vitro, platelets show normal activation and aggregation responses to major platelet agonists; integrin-mediated clot retraction and spreading of activated platelets on fibrinogen is normal

• ex vivo, platelets show normal adhesion and aggregate formation on collagen-coated surfaces under shear flow conditions