Analysis Tools
cellular
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• neural progenitor cells exhibit elongated cell cycle length, with a delay in progression through S- and G2/M-phases and significant lengthening of the G1 only in late (E16.5) cells
• the transition through the G1-R point is postponed
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growth/size/body
microcephaly
(
J:228026
)
|
• fully penetrant 20% smaller wet brain weight as embryos and continuing throughout life, particularly a reduction in cortical dimension
|
nervous system
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• extended corticogenesis
• neural progenitor cells carry out more P-N asymmetric-neurogenic divisions in young E12.5 embryos and more N-N symmetric-neurogenic divisions in older E14.5 embryos, always at the expense of P-P symmetric-proliferative divisions
• cortices at E18.5 show delayed astrogenesis
|
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• 20% smaller wet brain weight
|
|
• adults show thinning of the cortex stemming from a reduction of the superficial, later born layers II-IV and a corresponding increase in older and deeper layer VI cells
|
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• cortices at E18.5 show delayed astrogenesis
• astrocyte progenitors, RC2+ radial glia cells, show disturbed fiber alignment and fewer immature GFAP+ astrocytes are seen
|
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• progressive reduction of neural progenitor cell compartment at mid-to-late corticogenesis
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| microcephaly | DOID:10907 | J:228026 | ||
