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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ap2s1em1(IMPC)Tcp
endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI:5754583
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ap2s1em1(IMPC)Tcp/Ap2s1em1(IMPC)Tcp C57BL/6NCrl-Ap2s1em1(IMPC)Tcp/Cmmr MGI:6408241
ht2
 		Ap2s1em1(IMPC)Tcp/Ap2s1+ C57BL/6NCrl-Ap2s1em1(IMPC)Tcp/Tcp MGI:6261880


Genotype
MGI:6408241
hm1
Allelic
Composition		 Ap2s1em1(IMPC)Tcp/Ap2s1em1(IMPC)Tcp
Genetic
Background		 C57BL/6NCrl-Ap2s1em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap2s1em1(IMPC)Tcp mutation (1 available); any Ap2s1 mutation (14 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ap2s1em1(IMPC)Tcp/Ap2s1em1(IMPC)Tcp embryos are arrested prior to gastrulation with embryos recovered at E7.5 but not at E9.5. Embryos at E7.5 are smaller, without the presence of head folds, primitive node or primitive streak formation.

embryo
failure to gastrulate ( J:279207 )
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
decreased egg cylinder size ( J:279207 )
• a rudimentary egg cylinder is observed at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no embryonic node is present at E7.5
failure of primitive streak formation ( J:279207 )
• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are recovered at E7.5 (10% versus expected 25%, n=39) and arrest prior to gastrulation; no homozygous embryos are recovered at E9.5




Genotype
MGI:6261880
ht2
Allelic
Composition		 Ap2s1em1(IMPC)Tcp/Ap2s1+
Genetic
Background		 C57BL/6NCrl-Ap2s1em1(IMPC)Tcp/Tcp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap2s1em1(IMPC)Tcp mutation (1 available); any Ap2s1 mutation (14 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
enlarged cecum ( J:211773 )
IMPC - UCD

growth/size/body
decreased body length ( J:211773 )
IMPC - UCD




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory