All Phenotypes Cdk12<em1(IMPC)Tcp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk12^em1(IMPC)Tcp/Cdk12^em1(IMPC)Tcp	C57BL/6NCrl-Cdk12^em1(IMPC)Tcp/Tcp	MGI:6262090
ht2	Cdk12^em1(IMPC)Tcp/Cdk12⁺	C57BL/6NCrl-Cdk12^em1(IMPC)Tcp/Tcp	MGI:6262089

Allelic Composition	Cdk12^em1(IMPC)Tcp/Cdk12^em1(IMPC)Tcp
Genetic Background	C57BL/6NCrl-Cdk12^em1(IMPC)Tcp/Tcp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk12^em1(IMPC)Tcp mutation (2 available); any Cdk12 mutation (75 available)

Data Sources

IMPC Data for Cdk12

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - TCP

cardiovascular system

increased heart weight ( J:211773 )

IMPC - TCP

growth/size/body

increased heart weight ( J:211773 )

IMPC - TCP

enlarged urinary bladder ( J:211773 )

IMPC - TCP

enlarged spleen ( J:211773 )

IMPC - TCP

increased spleen weight ( J:211773 )

IMPC - TCP

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

IMPC - TCP

decreased hematocrit ( J:211773 )

IMPC - TCP

decreased hemoglobin content ( J:211773 )

IMPC - TCP

increased red blood cell distribution width ( J:211773 )

IMPC - TCP

abnormal spleen morphology ( J:211773 )

IMPC - TCP

enlarged spleen ( J:211773 )

IMPC - TCP

increased spleen weight ( J:211773 )

IMPC - TCP

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:211773 )

IMPC - TCP

immune system

abnormal spleen morphology ( J:211773 )

IMPC - TCP

enlarged spleen ( J:211773 )

IMPC - TCP

increased spleen weight ( J:211773 )

IMPC - TCP

liver/biliary system

abnormal liver morphology ( J:211773 )

IMPC - TCP

renal/urinary system

abnormal urinary bladder morphology ( J:211773 )

IMPC - TCP

enlarged urinary bladder ( J:211773 )

IMPC - TCP

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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