Phenotypes associated with this allele

• Allele Symbol: Klrb1b^tm1.1Apma
• Allele Name: targeted mutation 1.1, Andrew P Makrigiannis
• Allele ID: MGI:5755236
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klrb1b^tm1.1Apma/Klrb1b^tm1.1Apma	B6.Cg-Klrb1b^tm1.1Apma	MGI:5896643
cx2	Klrb1b^tm1.1Apma/Klrb1b^tm1.1Apma Tg(IghMyc)22Bri/0	involves: BALB/c * C57BL * C57BL/6 * SJL	MGI:5896645

Genotype
MGI:5896643

hm1

• Allelic Composition: Klrb1b^tm1.1Apma/Klrb1b^tm1.1Apma
• Genetic Background: B6.Cg-Klrb1b^tm1.1Apma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal NK cell physiology ( J:222057 )

• NK cells lack Klrb1b:Clec2d inhibitory signals compared with wild-type cells

• decreased rejection of Clec2d-deficient splenocytes compared with wild-type mice

• increased rejection of B2M-deficient splenocytes compared with wild-type mice

• however, mice exhibit normal response to YAC-1 and normal rejection of B2M-, Clec2d-deficient splenocytes

hematopoietic system

abnormal NK cell physiology ( J:222057 )

• NK cells lack Klrb1b:Clec2d inhibitory signals compared with wild-type cells

• decreased rejection of Clec2d-deficient splenocytes compared with wild-type mice

• increased rejection of B2M-deficient splenocytes compared with wild-type mice

• however, mice exhibit normal response to YAC-1 and normal rejection of B2M-, Clec2d-deficient splenocytes

Genotype
MGI:5896645

cx2

• Allelic Composition: Klrb1b^tm1.1Apma/Klrb1b^tm1.1Apma; Tg(IghMyc)22Bri/0
• Genetic Background: involves: BALB/c * C57BL * C57BL/6 * SJL

neoplasm

decreased tumor latency ( J:222057 )

• delayed onset of B cell lymphoma compared with Tg(IghMyc)22Bri mice