All Phenotypes Emilin2<tm1.2Jhp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Emilin2^tm1.2Jhp
targeted mutation 1.2, Jane Hoover-Plow
MGI:5755385

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Emilin2^tm1.2Jhp/Emilin2^tm1.2Jhp	involves: C57BL/6	MGI:5755408
cx2	Emilin1^tm1Gmb/Emilin1^tm1Gmb Emilin2^tm1.2Jhp/Emilin2^tm1.2Jhp	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5755409

Allelic Composition	Emilin2^tm1.2Jhp/Emilin2^tm1.2Jhp
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emilin2^tm1.2Jhp mutation (0 available); any Emilin2 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:226863 )

• delayed retraction of clots

• however, mice exhibit normal clotting time of platelet-rich plasma

decreased platelet aggregation ( J:226863 )

• negligible aggregation at low platelet concentrations

• suppressed aggregation in response to ADP, low doses of collagen to platelets in platelet-rich plasma and with washed platelets in response to thrombin

• however, aggregation is normal at higher platelet concentrations

abnormal response to injury ( J:226863 )

• at 4 hrs after FeCl3 carotid injury, patency is increased compared with wild-type mice

• however, occlusion time after injury is normal

hematopoietic system

decreased platelet aggregation ( J:226863 )

• negligible aggregation at low platelet concentrations

• suppressed aggregation in response to ADP, low doses of collagen to platelets in platelet-rich plasma and with washed platelets in response to thrombin

• however, aggregation is normal at higher platelet concentrations

Allelic Composition	Emilin1^tm1Gmb/Emilin1^tm1Gmb Emilin2^tm1.2Jhp/Emilin2^tm1.2Jhp
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emilin1^tm1Gmb mutation (0 available); any Emilin1 mutation (43 available)
Emilin2^tm1.2Jhp mutation (0 available); any Emilin2 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:226863 )

• mice exhibit delayed clot retraction compared with wild-type mice as in Emilin2^tm1.2Jhp homozygotes

• however, mice exhibit normal clotting time

decreased platelet aggregation ( J:226863 )

• in ADP platelet-rich plasma, with collagen stimulated platelets in platelet-rich plasma and with washed platelets stimulated with thrombin

• of ADP stimulated platelets

hematopoietic system

decreased platelet aggregation ( J:226863 )

• in ADP platelet-rich plasma, with collagen stimulated platelets in platelet-rich plasma and with washed platelets stimulated with thrombin

• of ADP stimulated platelets

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