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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Naipctm1Kmma
targeted mutation 1, Kendle M Maslowski
MGI:5755386
Summary 2 genotypes


Genotype
MGI:5896660
cn1
Allelic
Composition		 Naipctm1Kmma/Naipctm1Kmma
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 B6.Cg-Lyz2tm1(cre)Ifo Naipctm1Kmma
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Naipctm1Kmma mutation (0 available); any Naipc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased susceptibility to induced colitis ( J:222114 )
• mice treated with DSS exhibit a slight reduction of colitis in the early phase compared with control mice
• however, there is no protection after 9 days

neoplasm
neoplasm ( J:222114 )
N
• mice treated with azoxymethane and dextran sulfate sodium exhibit normal tumorigenesis

immune system
decreased susceptibility to induced colitis ( J:222114 )
• mice treated with DSS exhibit a slight reduction of colitis in the early phase compared with control mice
• however, there is no protection after 9 days




Genotype
MGI:5896658
cn2
Allelic
Composition		 Naipctm1Kmma/Naipctm1Kmma
Tg(Vil1-cre)997Gum/0
Genetic
Background		 B6.Cg-Naipctm1Kmma Tg(Vil1-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Naipctm1Kmma mutation (0 available); any Naipc mutation (0 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:222114 )
• in mice treated with azoxymethane and dextran sulfate sodium

digestive/alimentary system
decreased susceptibility to induced colitis ( J:222114 )
• mice treated with DSS exhibit reduced severity of colitis, weight loss and colon shortening compared with control mice

growth/size/body
decreased susceptibility to weight loss ( J:222114 )
• in DSS-treated mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:222114 )
• in mice treated with azoxymethane and dextran sulfate sodium

immune system
decreased susceptibility to induced colitis ( J:222114 )
• mice treated with DSS exhibit reduced severity of colitis, weight loss and colon shortening compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory