Phenotypes associated with this allele

• Allele Symbol: Naipc^tm1.1Kmma
• Allele Name: targeted mutation 1.1, Kendle M Maslowski
• Allele ID: MGI:5755387
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Naipc^tm1.1Kmma/Naipc^tm1.1Kmma	involves: BALB/cJ * C57BL/6	MGI:5896656

Genotype
MGI:5896656

hm1

• Allelic Composition: Naipc^tm1.1Kmma/Naipc^tm1.1Kmma
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased enterocyte apoptosis ( J:222114 )

• AOM-treated mice exhibit reduced apoptosis in the colon

digestive/alimentary system

decreased enterocyte apoptosis ( J:222114 )

• AOM-treated mice exhibit reduced apoptosis in the colon

decreased susceptibility to induced colitis ( J:222114 )

• mice treated with DSS exhibit reduced severity of colitis, weight loss and colon shortening compared with control mice

growth/size/body

decreased susceptibility to weight loss ( J:222114 )

• in DSS-treated mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:222114 )

• mice treated with azoxymethane (AOM) and dextran sulfate sodium (DSS) exhibit increased high-grade dysplasia tumor burden and tumor size compared with control mice

• mice treated with AOM alone exhibit increased tumor burden and tumor size compared with control mice

immune system

decreased susceptibility to induced colitis ( J:222114 )

• mice treated with DSS exhibit reduced severity of colitis, weight loss and colon shortening compared with control mice

decreased interleukin-1 beta secretion ( J:222114 )

• in bone marrow-derived macrophages infected with Salmonella typhimurium

• however, priming with LPS results in normal induction of pro-IL1beta and activation with poly(dA:dT) produce normal activation

neoplasm

increased incidence of tumors by chemical induction ( J:222114 )

• mice treated with azoxymethane (AOM) and dextran sulfate sodium (DSS) exhibit increased high-grade dysplasia tumor burden and tumor size compared with control mice

• mice treated with AOM alone exhibit increased tumor burden and tumor size compared with control mice