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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dynll1tm1.1Jhh
targeted mutation 1.1, Jorg Heierhorst
MGI:5755433
Summary 3 genotypes


Genotype
MGI:5755671
hm1
Allelic
Composition		 Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Genetic
Background		 C57BL/6NTac-Dynll1tm1.1Jhh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynll1tm1.1Jhh mutation (4 available); any Dynll1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:230105 )
• mice are viable and indistinguishable from wild-type mice




Genotype
MGI:5755454
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Genetic
Background		 B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dynll1tm1.1Jhh mutation (4 available); any Dynll1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell morphology ( J:230105 )
• 2-fold in pro-B/pre-B
decreased immature B cell number ( J:230105 )
• 8-fold in the bone marrow
decreased mature B cell number ( J:230105 )
• 4-fold in the spleen
decreased pre-B cell number ( J:230105 )
• in the bone marrow

hematopoietic system
abnormal B cell morphology ( J:230105 )
• 2-fold in pro-B/pre-B
decreased immature B cell number ( J:230105 )
• 8-fold in the bone marrow
decreased mature B cell number ( J:230105 )
• 4-fold in the spleen
decreased pre-B cell number ( J:230105 )
• in the bone marrow




Genotype
MGI:5755458
cn3
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Tg(IghMyc)22Bri/0
Genetic
Background		 B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dynll1tm1.1Jhh mutation (4 available); any Dynll1 mutation (20 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased immature B cell number ( J:230105 )
• greater than 50-fold

neoplasm
decreased lymphoma incidence ( J:230105 )
• compared with Tg(IghMyc)22Bri mice

hematopoietic system
decreased immature B cell number ( J:230105 )
• greater than 50-fold




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory