Phenotypes associated with this allele

• Allele Symbol: Brd7^tm1.2Ligy
• Allele Name: targeted mutation 1.2, Guiyuan Li
• Allele ID: MGI:5755484
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brd7^tm1.2Ligy/Brd7^tm1.2Ligy	involves: 129S4/SvJaeSor * C57BL/6J * FVB/N	MGI:6758257
hm2	Brd7^tm1.2Ligy/Brd7^tm1.2Ligy	involves: C57BL/6	MGI:5755485

Genotype
MGI:6758257

hm1

• Allelic Composition: Brd7^tm1.2Ligy/Brd7^tm1.2Ligy
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:251649 )

♂

abnormal sperm head morphology ( J:251649 )

♂ • with absent or deformed acrosome

abnormal acrosome morphology ( J:251649 )

♂ • absent or deformed acrosome

globozoospermia ( J:251649 )

♂

absent acrosome ( J:251649 )

♂

abnormal spermatid morphology ( J:251649 )

♂

increased male germ cell apoptosis ( J:251649 )

♂

small seminiferous tubules ( J:251649 )

♂

small testis ( J:251649 )

♂

decreased testis weight ( J:251649 )

♂

arrest of spermatogenesis ( J:251649 )

♂ • at step 13

male infertility ( J:251649 )

♂

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:251649 )

♂N • mice exhibit normal levels of serum testosterone, estradiol hormone, and follicle-stimulating hormone

endocrine/exocrine glands

small seminiferous tubules ( J:251649 )

♂

small testis ( J:251649 )

♂

decreased testis weight ( J:251649 )

♂

cellular

azoospermia ( J:251649 )

♂

abnormal sperm head morphology ( J:251649 )

♂ • with absent or deformed acrosome

abnormal acrosome morphology ( J:251649 )

♂ • absent or deformed acrosome

globozoospermia ( J:251649 )

♂

absent acrosome ( J:251649 )

♂

abnormal spermatid morphology ( J:251649 )

♂

increased male germ cell apoptosis ( J:251649 )

♂

Genotype
MGI:5755485

hm2

• Allelic Composition: Brd7^tm1.2Ligy/Brd7^tm1.2Ligy
• Genetic Background: involves: C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:223952 )

N • mice exhibit normal anxiety and depression behaviors in an open field, light-dark box or forced swim test

abnormal long-term object recognition memory ( J:223952 )

• decreased discrimination ratio

impaired short-term object recognition memory ( J:223952 )

• decreased discrimination ratio

impaired spatial learning ( J:223952 )

• increased latency to reach the platform during training and latency to cross the platform on the test day in a Morris water maze test

• mice exhibit reduced entries in the platform zone on test day in a Morris water maze test compared with wild-type mice

• mice spend less time in the new arm of a Y-maze compared with wild-type mice

• however, number of entries in a Y-maze is normal

abnormal social/conspecific interaction behavior ( J:223952 )

• mice spend less time in the social target side compared with wild-type mice

nervous system

nervous system phenotype ( J:223952 )

N • mice exhibit normal neuron survival

abnormal dendrite morphology ( J:223952 )

• reduced apical dendritic branching, basal dendritic branching and basal dendritic spines in the medial prefrontal cortex

• however, mice exhibit normal apical dendritic branching, basal dendritic branching, apical dendrite spines and basal dendrite spines in the hippocampus