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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dctn6em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5755486
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dctn6em1(IMPC)J/Dctn6em1(IMPC)J C57BL/6NJ-Dctn6em1(IMPC)J/J MGI:6262259
ht2
 		Dctn6em1(IMPC)J/Dctn6+ C57BL/6NJ-Dctn6em1(IMPC)J/J MGI:7628960


Genotype
MGI:6262259
hm1
Allelic
Composition		 Dctn6em1(IMPC)J/Dctn6em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Dctn6em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dctn6em1(IMPC)J mutation (1 available); any Dctn6 mutation (15 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Dctn6em1(IMPC)J/Dctn6em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as normal blastocysts but not at E7.5. Blastocysts grown in culture fail to hatch from the zona pellucida and to form a typical outgrowth colony.

embryo
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• blastocysts fail to hatch from the zona pellucida with apparent cell death after 3 days in culture
absent embryonic epiblast ( J:279207 )
• no epiblast cells are observed after 3 days in culture
absent primitive endoderm ( J:279207 )
• no primitive endoderm (PrE) cells are observed after 3 days in culture
absent trophectoderm ( J:279207 )
• no trophectoderm (TE) is observed after 3 days in culture

mortality/aging
embryonic lethality before implantation, complete penetrance ( J:279207 )
• normal blastocysts are present at lower than expected Mendelian ratios at E3.5 (15% versus 25%, n=33); no embryos or excess resorption sites are observed at E7.5

reproductive system
failure of embryo implantation ( J:279207 )
• blastocysts fail to hatch and form a typical outgrowth colony after 3 days in culture (no TE/PrE/epiblast)




Genotype
MGI:7628960
ht2
Allelic
Composition		 Dctn6em1(IMPC)J/Dctn6+
Genetic
Background		 C57BL/6NJ-Dctn6em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dctn6em1(IMPC)J mutation (1 available); any Dctn6 mutation (15 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory