About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp1r12aem1Sfsh
endonuclease-mediated mutation 1, Steven A Fisher
MGI:5755518
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppp1r12aem1Sfsh/Ppp1r12a+
Tg(Myh11-icre/ERT2)1Soff/0 		involves: C57BL/6J * FVB/N MGI:5776052


Genotype
MGI:5776052
cn1
Allelic
Composition		 Ppp1r12aem1Sfsh/Ppp1r12a+
Tg(Myh11-icre/ERT2)1Soff/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r12aem1Sfsh mutation (1 available); any Ppp1r12a mutation (62 available)
Tg(Myh11-icre/ERT2)1Soff mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel physiology ( J:230106 )
• tamoxifen-treated mice exhibit a 5-fold increase in sensitivity to 8-Br-cGMP under calcium clamp and increased maximal relaxation in mesenteric arteries compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory