Analysis Tools
mortality/aging
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• almost all mice sensitized with ovalbumin and alum twice and then intranasally challenged with ovalbumin six times die unlike wild-type mice
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immune system
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• mice exhibit normal numbers of numbers of peripheral lymphocytes, eosinophils and neutrophils
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• mice sensitized with ovalbumin and alum twice then orally challenged with ovalbumin every other day exhibit increased weight loss, colon shortening and severe intestinal pathology with increased mass cell infiltration, ATP serum concentration, IL4 production from CD4+ T cells in the small intestine, large intestine, and mesenteric lymph nodes compared with wild-type mice
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• in the peripheral blood and spleen
• in the peripheral blood and lungs of mice sensitized with ovalbumin and alum twice and then intranasally challenged with ovalbumin six times
• however, mice transferred with wild-type bone marrow exhibit normal numbers
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• in the small and large intestines
• in the intestines of mice sensitized with ovalbumin and alum twice then orally challenged with ovalbumin every other day
• however, mice transferred with wild-type bone marrow exhibit normal numbers
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• highly activated basophils with defective ATP clearance and enhanced ATP responses
• however, treatment with a P2X7 antagonist A839977 reduces activation
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• highly activated mast cells with defective ATP clearance and enhanced ATP responses
• however, treatment with a P2X7 antagonist A839977 reduces activation
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• in untreated mice
• in ovalbumin challenged mice
• in mice sensitized with ovalbumin and alum twice and then intranasally challenged with ovalbumin six times
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• mice sensitized with TNP-specific IgE and intradermally challenged with TNP-ovalbumin exhibit increased ear swelling with increased number of infiltrating basophils, eosinophils and neutrophils compared with wild-type mice
• however, acute allergic response is normal and chronic inflammation is ameliorated by oxidized ATP treatment
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• in mice sensitized with ovalbumin and alum twice then orally challenged with ovalbumin every other day
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• mice sensitized with ovalbumin and alum twice and then intranasally challenged with ovalbumin six times exhibit increased lung infiltration of inflammatory cells and enhanced mucus production with increased basophil populations in the peripheral blood and the lung and increased serum IgE levels and ATP concentrations compared with wild-type mice
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digestive/alimentary system
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• in mice sensitized with ovalbumin and alum twice then orally challenged with ovalbumin every other day
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• mice sensitized with ovalbumin and alum twice then orally challenged with ovalbumin every other day exhibit increased weight loss, colon shortening and severe intestinal pathology with increased mass cell infiltration, ATP serum concentration, IL4 production from CD4+ T cells in the small intestine, large intestine, and mesenteric lymph nodes compared with wild-type mice
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growth/size/body
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• in mice sensitized with ovalbumin and alum twice then orally challenged with ovalbumin every other day
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respiratory system
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• mice sensitized with ovalbumin and alum twice and then intranasally challenged with ovalbumin six times exhibit increased lung infiltration of inflammatory cells and enhanced mucus production with increased basophil populations in the peripheral blood and the lung and increased serum IgE levels and ATP concentrations compared with wild-type mice
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hematopoietic system
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• in the peripheral blood and spleen
• in the peripheral blood and lungs of mice sensitized with ovalbumin and alum twice and then intranasally challenged with ovalbumin six times
• however, mice transferred with wild-type bone marrow exhibit normal numbers
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• in the small and large intestines
• in the intestines of mice sensitized with ovalbumin and alum twice then orally challenged with ovalbumin every other day
• however, mice transferred with wild-type bone marrow exhibit normal numbers
|
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• highly activated basophils with defective ATP clearance and enhanced ATP responses
• however, treatment with a P2X7 antagonist A839977 reduces activation
|
|
• highly activated mast cells with defective ATP clearance and enhanced ATP responses
• however, treatment with a P2X7 antagonist A839977 reduces activation
|
|
• in untreated mice
• in ovalbumin challenged mice
• in mice sensitized with ovalbumin and alum twice and then intranasally challenged with ovalbumin six times
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