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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stk11ipem1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5755625
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stk11ipem1(IMPC)J/Stk11ipem1(IMPC)J C57BL/6NJ-Stk11ipem1(IMPC)J/J MGI:6263590


Genotype
MGI:6263590
hm1
Allelic
Composition		 Stk11ipem1(IMPC)J/Stk11ipem1(IMPC)J
Genetic
Background		 C57BL/6NJ-Stk11ipem1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk11ipem1(IMPC)J mutation (1 available); any Stk11ip mutation (42 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:311895 )
N
• mice show normal blood pressure and no apparent differences in heart morphology or function at baseline
decreased response of heart to induced stress ( J:311895 )
• mice show attenuation of isoproterenol (a beta-adrenoreceptor agonist)-induced cardiac hypertrophy, with mice showing lower diastolic interventricular septal thickness, systolic interventricular septal thickness, diastolic and systolic left ventricular posterior wall, ratios of heart weight/body weight and heart weight/tibia length, attenuated hypertrophic myocardial area and cardiomyocyte area, greatly decreased interstitial and perivascular fibrosis, and reduced expression of cardiac hypertrophy-related genes than in wild-type mice
• mice show attenuation of pressure overload-induced cardiac hypertrophy, with mice subjected to transverse aortic constriction showing reduced left ventricular wall thickness, heart weight/body weight ratio, heart weight/tibia length ratio, cardiomyocyte size, and perivascular and interstitial fibrosis and alleviation of the ejection fraction and fractional shortening seen in wild-type mice
• however, mice with ISO-induced or pressure overload-induced cardiac hypertrophy show no difference from wild-type mice in the increase in capillary and arteriolar density

homeostasis/metabolism
decreased response of heart to induced stress ( J:311895 )
• mice show attenuation of isoproterenol (a beta-adrenoreceptor agonist)-induced cardiac hypertrophy, with mice showing lower diastolic interventricular septal thickness, systolic interventricular septal thickness, diastolic and systolic left ventricular posterior wall, ratios of heart weight/body weight and heart weight/tibia length, attenuated hypertrophic myocardial area and cardiomyocyte area, greatly decreased interstitial and perivascular fibrosis, and reduced expression of cardiac hypertrophy-related genes than in wild-type mice
• mice show attenuation of pressure overload-induced cardiac hypertrophy, with mice subjected to transverse aortic constriction showing reduced left ventricular wall thickness, heart weight/body weight ratio, heart weight/tibia length ratio, cardiomyocyte size, and perivascular and interstitial fibrosis and alleviation of the ejection fraction and fractional shortening seen in wild-type mice
• however, mice with ISO-induced or pressure overload-induced cardiac hypertrophy show no difference from wild-type mice in the increase in capillary and arteriolar density

mortality/aging
mortality/aging ( J:311895 )
N
• mice are viable




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory