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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eipr1em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5755665
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eipr1em1(IMPC)J/Eipr1em1(IMPC)J C57BL/6NJ-Eipr1em1(IMPC)J/J MGI:6262360
ht2
 		Eipr1em1(IMPC)J/Eipr1+ C57BL/6NJ-Eipr1em1(IMPC)J/J MGI:6262359


Genotype
MGI:6262360
hm1
Allelic
Composition		 Eipr1em1(IMPC)J/Eipr1em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Eipr1em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eipr1em1(IMPC)J mutation (1 available); any Eipr1 mutation (31 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Eipr1em1(IMPC)J/Eipr1em1(IMPC)J mice exhibit embryonic lethality after E7.5 but before E9.5. Embryos form a rudimentary egg-cylinder but no primitive streak or signs of gastrulation are seen at E7.5.

embryo
failure to gastrulate ( J:279207 )
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
decreased egg cylinder size ( J:279207 )
• a rudimentary egg cylinder is observed at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no embryonic node is present at E7.5
failure of primitive streak formation ( J:279207 )
• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are present at E7.5 (31% versus expected 25%, n=13); no homozygous embryos are recovered at E9.5




Genotype
MGI:6262359
ht2
Allelic
Composition		 Eipr1em1(IMPC)J/Eipr1+
Genetic
Background		 C57BL/6NJ-Eipr1em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eipr1em1(IMPC)J mutation (1 available); any Eipr1 mutation (31 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory