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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe
targeted mutation 20, Scott Lowe
MGI:5755843
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+ involves: 129S4/SvJae * C57BL/6 MGI:5755881
cn2
 		Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ 		involves: 129S4/SvJae * C57BL/6 MGI:5755882


Genotype
MGI:5755881
ht1
Allelic
Composition		 Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe mutation (0 available); any Col1a1 mutation (163 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:222595 )
N
• doxycycline-treated mice exhibit normal crypt proliferation, differentiation and Paneth cell production




Genotype
MGI:5755882
cn2
Allelic
Composition		 Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe mutation (0 available); any Col1a1 mutation (163 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
ectopic Paneth cells ( J:222595 )
• increased in doxycycline-treated mice
abnormal small intestinal crypt cell physiology ( J:222595 )
• doxycycline-treated mice exhibit dramatic hyper-proliferation and crypt expansion, blocked differentiation and ectopic Paneth cell production compared with control mice
abnormal small intestinal crypt cell proliferation ( J:222595 )
• increased in doxycycline-treated mice

cellular
abnormal small intestinal crypt cell proliferation ( J:222595 )
• increased in doxycycline-treated mice

endocrine/exocrine glands
ectopic Paneth cells ( J:222595 )
• increased in doxycycline-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory