Phenotypes associated with this allele

• Allele Symbol: Kctd12^tm1.1Bet
• Allele Name: targeted mutation 1.1, Bernhard Bettler
• Allele ID: MGI:5756044
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kctd12^tm1.1Bet/Kctd12^tm1.1Bet	B6.Cg-Kctd12^tm1.1Bet	MGI:5756048

Genotype
MGI:5756048

hm1

• Allelic Composition: Kctd12^tm1.1Bet/Kctd12^tm1.1Bet
• Genetic Background: B6.Cg-Kctd12^tm1.1Bet

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:227160 )

N • mice exhibit normal contextual conditioning and memory, pain sensitivity, locomotor activity, innate anxiety and sugar preference

enhanced cued conditioning behavior ( J:227160 )

• during auditory tone-electroshock fear conditioning, mice exhibit increased fear-freezing during trials compared with wild-type mice

• however, next day fear expression was normal

abnormal locomotor behavior ( J:227160 )

• during the light phase, mice exhibit more corner visits and water licks compared with wild-type mice

• however, nosepoke numbers are normal

nervous system

abnormal nervous system electrophysiology ( J:227160 )

• CA1 pyramidal neurons exhibit increased input resistance and action potential threshold and decreased rheobase current and action potential delay compared with wild-type mice

• pyramidal neurons exhibit increased intrinsic excitability compared with wild-type cells

• however, membrane potential is normal

abnormal action potential ( J:227160 )

• CA1 pyramidal neurons exhibit decreased rheobase current and action potential delay compared with wild-type mice

integument

integument phenotype ( J:227160 )

N • mice exhibit normal pain sensitivity