immune system
• by 12-16 weeks of age
• lymphocyte populations appear grossly normal by flow cytometric analysis and immunoglobulin levels.
|
• mutant mice develop variable proliferative and membranous glomerulonephritis with partially dominant and penetrant inheritance by 12-16 weeks of age.
|
renal/urinary system
• mutant mice develop variable proliferative and membranous glomerulonephritis with partially dominant and penetrant inheritance by 12-16 weeks of age.
|