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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eef2ktm1.1Cgpd
targeted mutation 1.1, Christopher G Proud
MGI:5759976
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eef2ktm1.1Cgpd/Eef2ktm1.1Cgpd involves: C57BL/6 MGI:5759983


Genotype
MGI:5759983
hm1
Allelic
Composition		 Eef2ktm1.1Cgpd/Eef2ktm1.1Cgpd
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef2ktm1.1Cgpd mutation (0 available); any Eef2k mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased sensitivity to induced cell death ( J:224568 )
• 2-DG-treated mouse embryonic fibroblasts exhibit greater sub-G1 cell accumulation after 48 h compared with wild-type cells

nervous system
abnormal neuron physiology ( J:224411 )
• following hypoxia, neurons exhibit greater depletion of ATP and increased cleavage of poly ADP-ribose polymerase compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory