Phenotypes associated with this allele

• Allele Symbol: Pitx2^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5760000
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pitx2^tm1b(EUCOMM)Wtsi/Pitx2^tm1b(EUCOMM)Wtsi	C57BL/6N-Pitx2^tm1b(EUCOMM)Wtsi/H	MGI:5767764
ht2	Pitx2^tm1b(EUCOMM)Wtsi/Pitx2^+	C57BL/6N-Pitx2^tm1b(EUCOMM)Wtsi/H	MGI:5767763

Genotype
MGI:5767764

hm1

• Allelic Composition: Pitx2^{tm1b(EUCOMM)Wtsi}/Pitx2^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Pitx2^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0688_3_A07

Data Sources

IMPC Data for Pitx2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:211773 )

IMPC - HAR

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:5767763

ht2

• Allelic Composition: Pitx2^{tm1b(EUCOMM)Wtsi}/Pitx2⁺
• Genetic Background: C57BL/6N-Pitx2^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0688_3_A07

Data Sources

IMPC Data for Pitx2

behavior/neurological

increased grip strength ( J:211773 )

♀

IMPC - HAR

cardiovascular system

enlarged heart ( J:211773 )

♀

IMPC - HAR

craniofacial

abnormal tooth morphology ( J:211773 )

♂

IMPC - HAR

endocrine/exocrine glands

small testis ( J:211773 )

♂

IMPC - HAR

growth/size/body

enlarged heart ( J:211773 )

♀

IMPC - HAR

abnormal tooth morphology ( J:211773 )

♂

IMPC - HAR

nervous system

abnormal optic disk morphology ( J:211773 )

♀

IMPC - HAR

reproductive system

small testis ( J:211773 )

♂

IMPC - HAR

skeleton

abnormal tooth morphology ( J:211773 )

♂

IMPC - HAR

vision/eye

abnormal optic disk morphology ( J:211773 )

♀

IMPC - HAR

irregularly shaped pupil ( J:211773 )

IMPC - HAR

cornea opacity ( J:211773 )

IMPC - HAR