Analysis Tools
immune system
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• mice are highly susceptible to sporadic CJD, with a 100% attack rate, extremely short and consistent incubation periods
• mice are less susceptible to variant CJD, with only 1/4 developing clinical disease, however all mice show evidence of sub-clinical prion infection
• vCJD-inoculated mice develop abundant PRNP (Prp) plaques, many of the florid type of a central plaque core surrounded by a ring of spongiform vacuoles
• mice are less susceptible to BSE, with no mice developing clinical signs, however 9/12 show evidence of sub-clinical prion infection
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