Phenotypes associated with this allele

• Allele Symbol: Appl2^tm1Smoc
• Allele Name: targeted mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:5762674
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Appl2^tm1Smoc/Appl2^tm1Smoc Tg(Ckmm-cre)5Khn/0	involves: FVB	MGI:5762817

Genotype
MGI:5762817

cn1

• Allelic Composition: Appl2^tm1Smoc/Appl2^tm1Smoc; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:230004 )

N • mice exhibit normal fasting glucose and insulin levels

improved glucose tolerance ( J:230004 )

• in response to glucose challenge

increased insulin sensitivity ( J:230004 )

• determined by insulin tolerance testing

muscle

increased skeletal muscle cell glucose uptake ( J:230004 )

• increased glucose uptake in extensor digitorum longus or soleus muscles compared with control muscles

behavior/neurological

behavior/neurological phenotype ( J:230004 )

N • mice exhibit normal food intake

growth/size/body

growth/size/body region phenotype ( J:230004 )

N • mice exhibit normal body weight

cellular

increased skeletal muscle cell glucose uptake ( J:230004 )

• increased glucose uptake in extensor digitorum longus or soleus muscles compared with control muscles