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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ywhaetm2.1Awb
targeted mutation 2.1, Anthony Wynshaw-Boris
MGI:5762859
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267026
cn2
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267027
cn3
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267030
cn4
Ywhaetm2.1Awb/Ywhaetm2.1Awb
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267034
cn5
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267035
cn6
Ywhaetm2.1Awb/Ywhae+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267036
cn7
Ywhaetm2.1Awb/Ywhaetm2.1Awb
Tg(Zp3-cre)93Knw/0
involves: C57BL/6J MGI:6380704


Genotype
MGI:6267026
cn1
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are embryonic lethal




Genotype
MGI:6267027
cn2
Allelic
Composition
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although mice are able to survive to adulthood, their survival rate is lower than expected

growth/size/body
• at P21, mice show significantly decreased body weight relative to control mice

pigmentation
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 1.09 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 1.09 cm2
• however, no white patches were observed on the tail and paws or any other region

craniofacial
N
• at P21, mice exhibit no obvious defects in the craniofacial region




Genotype
MGI:6267030
cn3
Allelic
Composition
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at P21, 88.5 % of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.69 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 88.5 % of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.69 cm2
• however, no white patches were observed on the tail and paws or any other region




Genotype
MGI:6267034
cn4
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.23 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.23 cm2
• however, no white patches were observed on the tail and paws or any other region




Genotype
MGI:6267035
cn5
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at P21, 100% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.97 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 100% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.97 cm2
• however, no white patches were observed on the tail and paws or any other region




Genotype
MGI:6267036
cn6
Allelic
Composition
Ywhaetm2.1Awb/Ywhae+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• at P21, mice do not show white patches of fur on the ventral region of their torso or any other region




Genotype
MGI:6380704
cn7
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
Tg(Zp3-cre)93Knw/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)93Knw mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• oocytes exhibit normal oogenesis, in vitro oocyte maturation and in vivo breeding





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory