About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ywhaetm2.1Awb
targeted mutation 2.1, Anthony Wynshaw-Boris
MGI:5762859
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267026
cn2
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267027
cn3
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267030
cn4
Ywhaetm2.1Awb/Ywhaetm2.1Awb
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267034
cn5
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267035
cn6
Ywhaetm2.1Awb/Ywhae+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267036
cn7
Ywhaetm2.1Awb/Ywhaetm2.1Awb
Tg(Zp3-cre)93Knw/0
involves: C57BL/6J MGI:6380704


Genotype
MGI:6267026
cn1
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are embryonic lethal




Genotype
MGI:6267027
cn2
Allelic
Composition
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although mice are able to survive to adulthood, their survival rate is lower than expected

growth/size/body
• at P21, mice show significantly decreased body weight relative to control mice

pigmentation
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 1.09 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 1.09 cm2
• however, no white patches were observed on the tail and paws or any other region

craniofacial
N
• at P21, mice exhibit no obvious defects in the craniofacial region




Genotype
MGI:6267030
cn3
Allelic
Composition
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at P21, 88.5 % of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.69 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 88.5 % of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.69 cm2
• however, no white patches were observed on the tail and paws or any other region




Genotype
MGI:6267034
cn4
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.23 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.23 cm2
• however, no white patches were observed on the tail and paws or any other region




Genotype
MGI:6267035
cn5
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at P21, 100% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.97 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 100% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.97 cm2
• however, no white patches were observed on the tail and paws or any other region




Genotype
MGI:6267036
cn6
Allelic
Composition
Ywhaetm2.1Awb/Ywhae+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• at P21, mice do not show white patches of fur on the ventral region of their torso or any other region




Genotype
MGI:6380704
cn7
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
Tg(Zp3-cre)93Knw/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)93Knw mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• oocytes exhibit normal oogenesis, in vitro oocyte maturation and in vivo breeding





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory