Phenotypes associated with this allele

• Allele Symbol: Sik2^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5762866
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sik2^tm1Lex/Sik2^tm1Lex	involves: 129S/SvEvBrd	MGI:5762871

Genotype
MGI:5762871

hm1

• Allelic Composition: Sik2^tm1Lex/Sik2^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased fatty acid oxidation ( J:229999 )

• decrease in fatty acid oxidation in primary hepatocytes

increased circulating glucose level ( J:229999 )

• slight increase in blood glucose levels

increased circulating insulin level ( J:229999 )

• mild increase in insulin levels

increased circulating triglyceride level ( J:229999 )

• increase in plasma triglyceride levels

• however, triglyceride levels in the liver of regular diet or high-fat diet fed mice are normal

decreased energy expenditure ( J:229999 )

decreased respiratory quotient ( J:229999 )

impaired glucose tolerance ( J:229999 )

• impaired glucose tolerance

insulin resistance ( J:229999 )

• impaired insulin tolerance

decreased circulating adiponectin level ( J:229999 )

• decrease in plasma levels of total and high-molecular weight adiponectin

enhanced lipolysis ( J:229999 )

• primary adipocytes show increased lipolysis and decreased fatty acid uptake

adipose tissue

abnormal fat cell differentiation ( J:229999 )

• preadipocytes differentiate into adipocytes at a faster rate than wild-type preadipocytes

increased white fat cell size ( J:229999 )

• mice exhibit an increased population of larger white adipocytes both under normal diet and high-fat diet conditions

• however, no changes in adiposity or total fat mass are seen

decreased adipocyte glucose uptake ( J:229999 )

• preadipocytes show decreased 2-deoxyglucose uptake in response to insulin

behavior/neurological

decreased food intake ( J:229999 )

• slight decrease in food intake

increased locomotor activity ( J:229999 )

• slight increase in locomotor activity

cellular

abnormal fat cell differentiation ( J:229999 )

• preadipocytes differentiate into adipocytes at a faster rate than wild-type preadipocytes

decreased adipocyte glucose uptake ( J:229999 )

• preadipocytes show decreased 2-deoxyglucose uptake in response to insulin

decreased muscle cell glucose uptake ( J:229999 )

• reduction in glucose uptake from the muscle

decreased fatty acid oxidation ( J:229999 )

• decrease in fatty acid oxidation in primary hepatocytes

immune system

increased inflammatory response ( J:229999 )

• increase in macrophage infiltration into fat cells

muscle

decreased muscle cell glucose uptake ( J:229999 )

• reduction in glucose uptake from the muscle