Phenotypes associated with this allele

• Allele Symbol: Tgfb1i1^tm1.1Knos
• Allele Name: targeted mutation 1.1, Kiyoshi Nose
• Allele ID: MGI:5762965
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgfb1i1^tm1.1Knos/Tgfb1i1^tm1.1Knos	involves: C57BL/6	MGI:5762999

Genotype
MGI:5762999

hm1

• Allelic Composition: Tgfb1i1^tm1.1Knos/Tgfb1i1^tm1.1Knos
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:223628 )

N • under normal conditions, arteries are structurally and functionally normal

abnormal vascular smooth muscle physiology ( J:223628 )

• increased vascular smooth muscle cell apoptosis following wire injury or mechanical stress

abnormal vascular wound healing ( J:223628 )

• following wire injury of femoral arteries, mice exhibit increased neointmal thickening and delayed media recovery with increased apoptosis of vascular smooth muscle cells compared with wild-type mice

homeostasis/metabolism

abnormal vascular wound healing ( J:223628 )

• following wire injury of femoral arteries, mice exhibit increased neointmal thickening and delayed media recovery with increased apoptosis of vascular smooth muscle cells compared with wild-type mice

muscle

abnormal vascular smooth muscle physiology ( J:223628 )

• increased vascular smooth muscle cell apoptosis following wire injury or mechanical stress