Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-NCOA3)#Mybr
• Allele Name: transgene insertion, Myles Brown
• Allele ID: MGI:5762986
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(MMTV-NCOA3)#Mybr/0	FVB/N-Tg(MMTV-NCOA3)#Mybr	MGI:5762988

Genotype
MGI:5762988

tg1

• Allelic Composition: Tg(MMTV-NCOA3)#Mybr/0
• Genetic Background: FVB/N-Tg(MMTV-NCOA3)#Mybr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased mammary gland epithelial cell proliferation ( J:93548 )

♀ • about 50% increase in mammary gland epithelial cell proliferation at 2 weeks of pregnancy

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:93548 )

♀

abnormal mammary gland morphology ( J:93548 )

♀ • mammary glands of virgin females are 30-40% larger in size starting at 4 weeks of age

♀ • mammary gland size is increased due to an increas in size of each cell not due to an increase in the number of epithelial cells

♀ • mammary glands show numerous hyperplastic, noninvasive focal lesions resembling mammary intraepithelial neoplasia, seen as early as 5 months of age, irrespective of reproductive history

♀ • squamous metaplasia and squamous cysts with central keratin debris are frequently seen

abnormal involution of the mammary gland ( J:93548 )

♀ • mammary glands 4 days after initiation of involution do not show collapse of the alveoli, at day 14 of involution, mammary glands are still undergoing involution, and at day 21, ducts fail to remodel and remain hypercellular, become dilated, and fill with secretions, indicating delayed involution

abnormal mammary gland epithelium morphology ( J:93548 )

♀ • mammary glands at 1 day postpartum show a disorganized epithelium

♀ • the average luminal mammary gland epithelial cell diameter is 2-fold larger than that of wild-type mice

♀ • the epithelial cell number per area in the mammary gland is 2.5-fold higher than in wild-type mice

abnormal mammary gland duct morphology ( J:93548 )

♀ • ductal ectasia and increase in connective tissue

abnormal branching of the mammary ductal tree ( J:93548 )

♀ • mammary glands of pregnant mice show more extensive degree of ductal branching

mammary gland duct hyperplasia ( J:93548 )

♀ • ductal epithelial hyperplasia

abnormal mammary gland alveolus morphology ( J:93548 )

♀ • more extensive lobuloalveolar development is seen in mammary glands of females at 2 weeks of pregnancy compared to controls

♀ • alternations of the lobular architecture are frequently seen in virgin and resting mammary glands, including differentiating alveoli and secretory alveolar structures

increased mammary gland tumor incidence ( J:93548 )

♀ • mammary gland tumors are seen as early as 9 months of age, with an average latency of 16 months

♀ • frequency and latency of mammary tumors in nulliparous is not different from parous mice

♀ • several subtypes of adenocarcinomas are seen, including acinar, ductal, solid comedo type, and papillary adenocarcinoma

♀ • most tumors are invasive, infiltrating adjacent tissue like skeletal muscle or brain

increased mammary adenocarcinoma incidence ( J:93548 )

♀

mammary gland hyperplasia ( J:93548 )

♀ • hyperplasia and accelerated differentiation of mammary gland during pregnancy

abnormal mammary gland epithelium physiology ( J:93548 )

♀ • the number of epithelial cells undergoing apoptosis in the mammary glands is about 33% lower compared to wild-type mice on day 4 after the onset of involution

decreased mammary gland epithelial cell proliferation ( J:93548 )

♀ • about 50% increase in mammary gland epithelial cell proliferation at 2 weeks of pregnancy

homeostasis/metabolism

increased circulating insulin-like growth factor I level ( J:93548 )

♀ • circulating IGF-I levels are increased by about 2.5-fold

♀ • however, serum levels of growth hormone, prolactin, and luteinizing hormone are normal

integument

abnormal mammary gland morphology ( J:93548 )

♀ • mammary glands of virgin females are 30-40% larger in size starting at 4 weeks of age

♀ • mammary gland size is increased due to an increas in size of each cell not due to an increase in the number of epithelial cells

♀ • mammary glands show numerous hyperplastic, noninvasive focal lesions resembling mammary intraepithelial neoplasia, seen as early as 5 months of age, irrespective of reproductive history

♀ • squamous metaplasia and squamous cysts with central keratin debris are frequently seen

abnormal involution of the mammary gland ( J:93548 )

♀ • mammary glands 4 days after initiation of involution do not show collapse of the alveoli, at day 14 of involution, mammary glands are still undergoing involution, and at day 21, ducts fail to remodel and remain hypercellular, become dilated, and fill with secretions, indicating delayed involution

abnormal mammary gland epithelium morphology ( J:93548 )

♀ • mammary glands at 1 day postpartum show a disorganized epithelium

♀ • the average luminal mammary gland epithelial cell diameter is 2-fold larger than that of wild-type mice

♀ • the epithelial cell number per area in the mammary gland is 2.5-fold higher than in wild-type mice

abnormal mammary gland duct morphology ( J:93548 )

♀ • ductal ectasia and increase in connective tissue

abnormal branching of the mammary ductal tree ( J:93548 )

♀ • mammary glands of pregnant mice show more extensive degree of ductal branching

mammary gland duct hyperplasia ( J:93548 )

♀ • ductal epithelial hyperplasia

abnormal mammary gland alveolus morphology ( J:93548 )

♀ • more extensive lobuloalveolar development is seen in mammary glands of females at 2 weeks of pregnancy compared to controls

♀ • alternations of the lobular architecture are frequently seen in virgin and resting mammary glands, including differentiating alveoli and secretory alveolar structures

increased mammary gland tumor incidence ( J:93548 )

♀ • mammary gland tumors are seen as early as 9 months of age, with an average latency of 16 months

♀ • frequency and latency of mammary tumors in nulliparous is not different from parous mice

♀ • several subtypes of adenocarcinomas are seen, including acinar, ductal, solid comedo type, and papillary adenocarcinoma

♀ • most tumors are invasive, infiltrating adjacent tissue like skeletal muscle or brain

increased mammary adenocarcinoma incidence ( J:93548 )

♀

mammary gland hyperplasia ( J:93548 )

♀ • hyperplasia and accelerated differentiation of mammary gland during pregnancy

abnormal mammary gland epithelium physiology ( J:93548 )

♀ • the number of epithelial cells undergoing apoptosis in the mammary glands is about 33% lower compared to wild-type mice on day 4 after the onset of involution

decreased mammary gland epithelial cell proliferation ( J:93548 )

♀ • about 50% increase in mammary gland epithelial cell proliferation at 2 weeks of pregnancy

muscle

increased leiomyosarcoma incidence ( J:93548 )

♀ • uterine leiomyosarcomas

nervous system

increased pituitary adenoma incidence ( J:93548 )

♀

respiratory system

increased lung adenocarcinoma incidence ( J:93548 )

♀

neoplasm

increased pituitary adenoma incidence ( J:93548 )

♀

increased mammary gland tumor incidence ( J:93548 )

♀ • mammary gland tumors are seen as early as 9 months of age, with an average latency of 16 months

♀ • frequency and latency of mammary tumors in nulliparous is not different from parous mice

♀ • several subtypes of adenocarcinomas are seen, including acinar, ductal, solid comedo type, and papillary adenocarcinoma

♀ • most tumors are invasive, infiltrating adjacent tissue like skeletal muscle or brain

increased mammary adenocarcinoma incidence ( J:93548 )

♀

increased leiomyosarcoma incidence ( J:93548 )

♀ • uterine leiomyosarcomas

increased metastatic potential ( J:93548 )

♀ • several adenocarcinomas are metastatic, showing tumor formation composed by the same original cell type in lung, bones, and kidney

increased lung adenocarcinoma incidence ( J:93548 )

♀

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:93548