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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mfsd14atm1Coll
targeted mutation 1, William Colledge
MGI:5763015
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mfsd14atm1Coll/Mfsd14atm1Coll involves: 129S/SvEv * 129S6/SvEvTac MGI:5763059


Genotype
MGI:5763059
hm1
Allelic
Composition		 Mfsd14atm1Coll/Mfsd14atm1Coll
Genetic
Background		 involves: 129S/SvEv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfsd14atm1Coll mutation (1 available); any Mfsd14a mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:230570 )
N
• female mice are fertile
absent sperm mitochondrial sheath ( J:230570 )
• with mitochondria located in the head region
oligozoospermia ( J:230570 )
• 100-lower number of sperm in the vas deferens compared with wild-type mice
• in the epididymis
• fewer elongated spermatid compared to in wild-type mice
• however, there is no difference in the number of spermatogonia, primary spermatocytes or round spermatids
abnormal sperm head morphology ( J:230570 )
• with abnormal nuclear condensation
absent acrosome ( J:230570 )
• likely due to a defect in vesicular trafficking from the Golgi and/or fusion
abnormal spermiogenesis ( J:230570 )
• severely disrupted
male infertility ( J:230570 )
• despite normal copulatory behavior and production of vaginal plugs after mating

growth/size/body
decreased body weight ( J:230570 )
• slightly in male mice

cellular
absent sperm mitochondrial sheath ( J:230570 )
• with mitochondria located in the head region
oligozoospermia ( J:230570 )
• 100-lower number of sperm in the vas deferens compared with wild-type mice
• in the epididymis
• fewer elongated spermatid compared to in wild-type mice
• however, there is no difference in the number of spermatogonia, primary spermatocytes or round spermatids
abnormal sperm head morphology ( J:230570 )
• with abnormal nuclear condensation
absent acrosome ( J:230570 )
• likely due to a defect in vesicular trafficking from the Golgi and/or fusion

endocrine/exocrine glands




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory