Phenotypes associated with this allele

• Allele Symbol: Mir188^em1Xhl
• Allele Name: endonuclease-mediated mutation 1, Xiang-Hang Luo
• Allele ID: MGI:5763032
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir188^em1Xhl/Mir188^em1Xhl	C57BL/6-Mir188^em1Xhl	MGI:5763048

Genotype
MGI:5763048

hm1

• Allelic Composition: Mir188^em1Xhl/Mir188^em1Xhl
• Genetic Background: C57BL/6-Mir188^em1Xhl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased femur compact bone thickness ( J:222099 )

• in aged mice

decreased internal diameter of femur ( J:222099 )

• in aged mice

increased bone volume ( J:222099 )

• in vertebra of aged mice

increased trabecular bone volume ( J:222099 )

• in aged mice

increased osteoblast cell number ( J:222099 )

• on the trabecular and endosteal bone surfaces

• however, mice exhibit normal numbers of osteoclasts

increased bone trabecula number ( J:222099 )

• in aged mice

decreased bone trabecular spacing ( J:222099 )

• in aged mice

abnormal skeleton development ( J:222099 )

• increased osteogenesis in bone marrow mesenchymal stem cells

• however, osteoclast formation is normal

increased bone ossification ( J:222099 )

• increased trabecular and endosteal bone formation rates in aged mice

• however, no difference is observed in 3 month old mice

increased bone stiffness ( J:222099 )

• in the tibia of aged mice

increased bone strength ( J:222099 )

• increased maximum load in the tibia of aged mice

adipose tissue

abnormal fat cell morphology ( J:222099 )

• decreased number and area of adipocytes in the bone marrow

abnormal fat cell differentiation ( J:222099 )

• reduced adipogenesis in bone marrow mesenchymal stem cells

limbs/digits/tail

increased femur compact bone thickness ( J:222099 )

• in aged mice

decreased internal diameter of femur ( J:222099 )

• in aged mice

cellular

abnormal fat cell differentiation ( J:222099 )

• reduced adipogenesis in bone marrow mesenchymal stem cells