Phenotypes associated with this allele

• Allele Symbol: Tg(Sp7-Mir188)1Xhl
• Allele Name: transgene insertion 1, Xiang-Hang Luo
• Allele ID: MGI:5763034
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Sp7-Mir188)1Xhl/0	C57BL/6-Tg(Sp7-Mir188)1Xhl	MGI:5763050

Genotype
MGI:5763050

tg1

• Allelic Composition: Tg(Sp7-Mir188)1Xhl/0
• Genetic Background: C57BL/6-Tg(Sp7-Mir188)1Xhl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased trabecular bone volume ( J:222099 )

• in femur and vertebra at 6 months of age

• in the femur at 6 and 12 months of age

• in the vertebra

decreased compact bone thickness ( J:222099 )

• in the femur at 6 and 12 months of age

decreased osteoblast cell number ( J:222099 )

• on the trabecular and endosteal bone surfaces

• however, mice exhibit normal numbers of osteoclasts

decreased bone trabecula number ( J:222099 )

• in the femur at 6 and 12 months of age

abnormal bone ossification ( J:222099 )

• reduced trabecular and endosteal bone formation rates

decreased bone strength ( J:222099 )

adipose tissue

abnormal fat cell morphology ( J:222099 )

• increased number and area of adipocytes in the bone marrow