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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(RNU6-RNAi:Rhox3)2Wilk
transgene insertion 2, Miles F Wilkinson
MGI:5763202
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rhoxtm1Wilk/Rhoxtm1Wilk
Tg(RNU6-RNAi:Rhox3)2Wilk/0
Tg(Stra8-icre)1Reb/0 		involves: 129 * FVB/NJ MGI:5763277
cn2
 		Tg(RNU6-RNAi:Rhox3)2Wilk/0
Tg(Stra8-icre)1Reb/0 		involves: FVB/NJ MGI:5763275


Genotype
MGI:5763277
cn1
Allelic
Composition		 Rhoxtm1Wilk/Rhoxtm1Wilk
Tg(RNU6-RNAi:Rhox3)2Wilk/0
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhoxtm1Wilk mutation (1 available); any Rhox mutation (1 available)
Tg(RNU6-RNAi:Rhox3)2Wilk mutation (0 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased male germ cell number ( J:229199 )
• dramatic reduction of post-meiotic germ cells
oligozoospermia ( J:229199 )
• dramatic
decreased testis weight ( J:229199 )
• 80% reduction

endocrine/exocrine glands
decreased testis weight ( J:229199 )
• 80% reduction

cellular
decreased male germ cell number ( J:229199 )
• dramatic reduction of post-meiotic germ cells
oligozoospermia ( J:229199 )
• dramatic




Genotype
MGI:5763275
cn2
Allelic
Composition		 Tg(RNU6-RNAi:Rhox3)2Wilk/0
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(RNU6-RNAi:Rhox3)2Wilk mutation (0 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatid morphology ( J:229199 )
• abnormal of elongated spermatids
oligozoospermia ( J:229199 )
• few sperm in the cauda epididymides (greater than 100 fold reduction)
abnormal male meiosis ( J:229199 )
• defective meiotic prophase
increased male germ cell apoptosis ( J:229199 )
• of pachytene spermatocyte in seminiferous epithelial cycle stage IV
• of spermatocytes undergoing meiotic metaphase in stage XII
• of abnormal elongated spermatids
small seminiferous tubules ( J:229199 )
• decreased diameter
decreased testis weight ( J:229199 )
• however, seminal vesicle weight is normal

cellular
abnormal spermatid morphology ( J:229199 )
• abnormal of elongated spermatids
oligozoospermia ( J:229199 )
• few sperm in the cauda epididymides (greater than 100 fold reduction)
abnormal male meiosis ( J:229199 )
• defective meiotic prophase
increased male germ cell apoptosis ( J:229199 )
• of pachytene spermatocyte in seminiferous epithelial cycle stage IV
• of spermatocytes undergoing meiotic metaphase in stage XII
• of abnormal elongated spermatids

endocrine/exocrine glands
small seminiferous tubules ( J:229199 )
• decreased diameter
decreased testis weight ( J:229199 )
• however, seminal vesicle weight is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory