Phenotypes associated with this allele

• Allele Symbol: Clic4^tm1.1Thor
• Allele Name: targeted mutation 1.1, Bernard Thorens
• Allele ID: MGI:5763611
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Clic4^tm1.1Thor/Clic4^tm1.1Thor Ins1^tm1.1(cre)Thor/Ins1^+	involves: C57BL/6J	MGI:5903885

Genotype
MGI:5903885

cn1

• Allelic Composition: Clic4^tm1.1Thor/Clic4^tm1.1Thor; Ins1^{tm1.1(cre)Thor}/Ins1⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:223517 )

N • when fed a high fat diet, mice show no differences in beta cell mass or in glucose tolerance and insulin secretion following intraperitoneal glucose injections relative to similarly treated control mice

endocrine/exocrine glands

decreased pancreatic islet cell apoptosis ( J:223517 )

• primary pancreatic islet cells exhibit reduced sensitivity to cytokines- or palmitic acid-induced apoptosis, as measured by a TUNEL assay

• islets show increased expression of the anti-apoptotic proteins Bcl2, Bcl2l1 (Bcl-xL), as well as increased expression and phosphorylation of Bad, which inhibits its pro-apoptotic activity

cellular

decreased pancreatic islet cell apoptosis ( J:223517 )

• primary pancreatic islet cells exhibit reduced sensitivity to cytokines- or palmitic acid-induced apoptosis, as measured by a TUNEL assay

• islets show increased expression of the anti-apoptotic proteins Bcl2, Bcl2l1 (Bcl-xL), as well as increased expression and phosphorylation of Bad, which inhibits its pro-apoptotic activity