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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dbn1tm1.1Lbc
targeted mutation 1.1, Gert Lubec
MGI:5763775
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dbn1tm1.1Lbc/Dbn1tm1.1Lbc B6.Cg-Dbn1tm1.1Lbc MGI:5784724
ht2
 		Dbn1tm1.1Lbc/Dbn1+ B6.Cg-Dbn1tm1.1Lbc MGI:5784725


Genotype
MGI:5784724
hm1
Allelic
Composition		 Dbn1tm1.1Lbc/Dbn1tm1.1Lbc
Genetic
Background		 B6.Cg-Dbn1tm1.1Lbc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1tm1.1Lbc mutation (0 available); any Dbn1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus morphology ( J:224553 )
• significant decrease in the levels of protein complexes containing the neurotransmitter receptors dopamine receptor D1, dopamine receptor D2, 5-hydroxytryptamine receptor 1A, and 5-hydroxytryptamine receptor 7 in the hippocampus
abnormal dendritic spine morphology ( J:224553 )
• significantly decreased immunoreactivity for dopamine receptor D1 (D1R) on hippocampal dendritic spines, with no apparent change in the shaft region
• total number of dendritic spines on apical dendrites of CA1 pyramidal cells is significantly reduced relative to wild-type controls
• markedly reduced number of mushroom, thin, and stubby dendritic spines on CA1 hippocampal neurons, whereas numbers of other unclassified types remain normal
impaired synaptic plasticity ( J:224553 )
• moderate but significant reduction in memory-related high-frequency-induced synaptic strengthening in hippocampal slices




Genotype
MGI:5784725
ht2
Allelic
Composition		 Dbn1tm1.1Lbc/Dbn1+
Genetic
Background		 B6.Cg-Dbn1tm1.1Lbc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1tm1.1Lbc mutation (0 available); any Dbn1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendritic spine morphology ( J:224553 )
• total number of dendritic spines on apical dendrites of CA1 pyramidal cells is significantly reduced relative to wild-type controls, but to a lesser extent than in homozygous mutants
• significant reduction in the number of mushroom and stubby dendritic spines on CA1 hippocampal neurons, whereas numbers of thin and other unclassified types remain normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory