Phenotypes associated with this allele

• Allele Symbol: Folh1^tm2Nle
• Allele Name: targeted mutation 2, Joseph H Neale
• Allele ID: MGI:5766053
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Folh1^tm2Nle/Folh1^tm2Nle	involves: 129S6/SvEvTac * C57BL/6J	MGI:5784727

Genotype
MGI:5784727

hm1

• Allelic Composition: Folh1^tm2Nle/Folh1^tm2Nle
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:224551 )

N • contrary to previous findings, uninjured mice develop normally with no overt differences in survival relative to wild-type controls

homeostasis/metabolism

decreased susceptibility to injury ( J:224551 )

• at 24 h after moderate traumatic brain injury (TBI), mice display significantly fewer Fluoro-Jade B (FJB)-stained degenerating neurons and astrocyte damage in the ipsilateral CA2/3 regions of the hippocampus relative to TBI subjected wild-type controls

nervous system

hippocampal neuron degeneration ( J:224551 )

• at 24 h after moderate TBI, mice display significantly fewer FJB-stained degenerating neurons in the ipsilateral CA2/3 regions of the hippocampus relative to TBI subjected wild-type controls

decreased astrocyte number ( J:224551 )

• at 24 h after moderate TBI, mice show a significantly reduced loss of GFAP-positive astrocytes in the ipsilateral CA2/3 regions of the hippocampus relative to TBI subjected wild-type controls

behavior/neurological

behavior/neurological phenotype ( J:224551 )

N • uninjured mice show no overt differences in neurological reflexes, reactivity, or performance in the open field, Morris water maze (MWM) or beam walk tests relative to wild-type controls

enhanced spatial learning ( J:224551 )

• after moderate TBI, mice show significantly shorter latencies to locate the hidden platform in a MWM test on days 13, 14, and 15 post-injury relative to TBI subjected wild-type controls

• however, swim speed is not significantly altered

enhanced coordination ( J:224551 )

• after moderate TBI, mice show significantly shorter latencies to cross the beam relative to TBI subjected wild-type controls on days 14, 21, and 28 post-injury